Florence Santa Maria Novella (ZMS) is Florence's main railway station, not an airport, so does Santa Maria Novella have a lounge has a simple answer: no, because there is no airport here to operate one. Travellers asking this are usually really asking about lounge access at Florence's actual air gateways, Florence Airport (FLR), also called Peretola or Amerigo Vespucci, and Pisa International Airport (PSA), the larger regional alternative an hour or so away by train.
Florence Airport is a compact city-side field with limited runway capacity, so its lounge picture is modest, generally a single small lounge or pay-in option rather than a wide network, reflecting the airport's constrained size within Florence's urban footprint. Pisa, serving as the broader Tuscany gateway with more international and low-cost carrier traffic, tends to carry a somewhat larger lounge and Priority Pass-style picture, though still well short of what a major national hub like Rome or Milan would offer.
Exactly which lounges operate at either airport, their current hours, and which cards or memberships they honor can change, particularly at a smaller field like Florence where facilities are limited by space. Confirm current details directly with Florence Airport or Pisa International Airport, or with your airline or card issuer, before counting on a specific access route.
For most travellers moving through Santa Maria Novella station on their way to a flight, the honest plan is to match your lounge expectations to whichever airport, Florence or Pisa, you are actually departing from, and to verify that airport's current lounge situation ahead of time rather than assuming Tuscany's air gateways mirror Italy's larger hubs. Santa Maria Novella station sits a short walk from Florence's historic center, so most travellers linger in the city before making the onward trip to whichever airport their flight actually uses. Build a realistic buffer for that transfer, since Tuscan rail and airport connections can run tighter than first-time visitors expect.