Jerry Tyler Memorial Airport in Niles, Michigan is a small general-aviation field, and honesty is the most useful thing to offer here: it does not host rental car desks of any kind, and travelers searching for car rental at this airport should redirect their plans rather than expect an on-site counter. Niles sits in the far southwestern corner of Michigan, close to the Indiana state line, and the practical solution for anyone needing a vehicle in this area is South Bend International Airport, roughly thirty to forty minutes southeast across the state line in Indiana, which offers a full complement of international and local rental companies.
For visitors already in the Niles area for other reasons, such as a private flight into Jerry Tyler Memorial or a visit to the region's small towns and rural attractions, arranging a car in advance through a South Bend rental desk and having someone drive it up, or taking a short rideshare or taxi to South Bend to complete the rental, tends to be the most workable approach. Michigan and Indiana both drive on the right, and the roads connecting Niles to South Bend are straightforward interstate and state highway driving with no unusual terrain to plan around at all.
Southwestern Michigan and the neighboring stretch of northern Indiana see genuine winter weather, including lake-effect snow bands off Lake Michigan roughly November through March, so if your trip falls in that window it is worth checking road conditions before driving between South Bend and Niles, since localized snow squalls in this region can reduce visibility quickly even when surrounding areas remain clear on an otherwise ordinary winter day near the state line.
Outside winter, the drive between South Bend and Niles is simple and scenic, passing through farmland and small towns typical of this quiet corner of the Midwest.